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Clonidine is a centrally acting antihypertensive (to lower high blood pressure) agent, used mainly for this purpose in the past. It has found new uses, including treatment of some types of neuropathic pain, opioid detoxification, and, off-label, to counter the side effects of stimulant medication such as Methylphenidate. It is also increasingly becoming a more accepted alternative to fight insomnia as the drug is less addictive than most prescription sleep aids. Because of the above effects, Clonidine is increasingly used in conjunction with stimulants to treat attention-deficit hyperactivity disorder ADHD where it's given late afternoon and/or evening for sleep and because it sometimes helps moderate ADHD associated impulsive and oppositional behavior and may reduce tics [1].

Clonidine is a centrally-acting alpha-2 agonist. It selectively stimulates receptors in the brain that monitor catecholamine levels in the blood. These receptors close a negative feedback loop that begins with descending sympathetic nerves from the brain that control the production of catecholamines (epinephrine, also known as adrenaline, and norepinephrine) in the adrenal medulla. By fooling the brain into believing that catecholamine levels are higher than they really are, clonidine causes the brain to reduce its signals to the adrenal medulla, which in turn lowers catecholamine production and blood levels. The result is a lowered heart rate and blood pressure, with side effects of dry mouth and fatigue. If clonidine is suddenly withdrawn the sympathetic nervous system will revert to producing high levels of epinephrine and norepinephrine, higher even than before treatment, causing rebound hypertension. Rebound hypertension can be avoided by slowly withdrawing treatment.

An analogy would be lowering the temperature of a house by holding a lit match under the thermostat connected to the furnace.

Acetaminophen (USAN) (brand names Tylenol® in US and Panadol® in UK), is a common analgesic and antipyretic drug that is used for the relief of fever, headaches, and other minor aches and pains. Paracetamol is also useful in managing more severe pain, allowing lower dosages of additional NSAID or opioid analgesics to be used, so minimising overall side-effects. It is a major ingredient in numerous cold and flu medications and many prescription analgesics. It is remarkably safe in recommended doses, but because of its wide availability, deliberate or accidental overdoses are fairly common.

The words acetaminophen and paracetamol both come from the chemical names for the compound: N-acetyl-para-aminophenol and para-acetyl-amino-phenol. In some contexts, it is shortened to apap, for N-acetyl-para-amino-phenol.

2006-07-22 10:05:59 · answer #1 · answered by Anonymous · 0 0

acetametaphine is the drug in tylenol the other not heard of are you sure you spelled it right?

2006-07-22 19:27:56 · answer #2 · answered by Autumn 5 · 0 0

acetaminaphen is tylenol. When I searched for cladidimine(cause I've never seen this before), nothing came up in the search. Did you mean Clonodine??? If so, that is also a blood pressure medicine.

2006-07-22 17:02:31 · answer #3 · answered by Anonymous · 0 0

Acetaminophen is a pain killer - such as Tylenol by brand name.

2006-07-22 17:00:47 · answer #4 · answered by Lydia 7 · 0 0

a·cet·a·min·o·phen (ə-sē'tə-mĭn'ə-fən, ăs'ə-)
n.
A crystalline compound, C8H9NO2, used in medicine to relieve pain and reduce fever.


I cannot find any trace of the other..............

2006-07-22 17:01:55 · answer #5 · answered by thomasrobinsonantonio 7 · 0 0

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