will Metformin aka Glucophage increase chances of multiple birth?

Question

i have recently been diagnosed with pcos, i have read all the info i can find on it. im trying to find out if it can cause me to have twins or more. im curriouse what the percentage is, if it even does increase the odds at all. i cant find any web sights to answer my question. f.y.i we are ttc our 3rd, the first 2 i had no problems with and as far as i know i havent had pcos long. any info is great thanx

my doc knows we are ttc, maybe since im still young (23) he didnt see the need for fertility drugs. i know its not a fertility drug but doc did say it would probably make me very fertile, so thast why i wondered about multiple births :)

Answer 1

It shouldn't.

The reason why it shouldn't is that metformin, unlike Clomid, does not actually "make" you ovulate. Instead, it makes it possible for the ovaries to release eggs as they normally would. Metformin treats insulin resistance, which causes most cases of PCOS. Insulin resistance is not the same thing as type 2 diabetes, but left untreated it can worsen until it becomes diabetes. Women with PCOS who are insulin resistant have excess insulin floating around in their bodies, which causes the ovaries to produce too many male hormones. This prevents ovulation from occurring. Metformin helps lower the amount of excess insulin, which in turn allows ovarian function to return to normal, which allows ovulation to occur as it normally would. Metformin does not contain any hormones and does not directly cause ovulation to happen--it's more like a chain reaction. So, you should not have any greater chance of multiple births on metformin than would a woman who ovulated normally. There is always a risk of multiple births for every woman who becomes pregnant, but metformin is not known to increase this risk.

Unfortunately, metformin is not sufficient to induce ovulation in all women with PCOS. Sometimes Clomid must be taken along with metformin in order to cause ovulation, and Clomid (being a true fertility drug) actually causes ovulation to happen. It has been associated with a higher rate of multiple births. Most women try using metformin alone before adding Clomid, and sometimes the use of metformin means that a smaller dose of Clomid is needed.

Answer 2

1

Answer 3

Metformin Increase Fertility

Answer 4

2

Answer 5

Metformin helps with Inculin resistance. It is not a fertility drug. It won't help with anything but your weight and insulin/sugar levels. PCOS causes you to be insulin resistant thus causing weight gain and all that jazz (according to the doc's). However, my specialist stated that Metformin is given to help regulate your sugar levels and to help lose weight so that you don't become a Type I diabetic, since technically, being Insulin Resistant from the PCOS you are a Type II diabetic. I was diagnosed with PCOS June of 05, however the docs think that I have had it since I was 16. I am now 27. If you are trying to conceive you should talk to your doc about Chlomide. Most docs tend to put you on BC to regulate the periods and Metformin for the insulin resistance. Once you want to conceive they take you off the BC, keep you on the Met, and put you on Chlomide. Which studies show that all fertility drugs increase the chance of multiple births.

Answer 6

I don't think Metformin causes multiple births. The only thing I have heard to cause multiple births are fertility drugs, like Clomid. The best thing you can do to get accurate information is talk to your doctor and/or your pharmacist and they should be able to give you the low down on the Metformin.

Answer 7

What should I avoid while taking metformin?

Avoid drinking alcohol. It lowers blood sugar and may increase your risk of lactic acidosis while taking metformin.


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Answer 8

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Answer 9

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Answer 10

polycystic ovarian cystitis?

As far as I know Metafomin is a pill that causes your pancreas to secrete insulin and enhances your cell's sensitivity to it... I had no idea that it had reproductive actions as well... ????