how does clomiphene helps in PCOS & what is the success rate?how long does it takes to get pregnant on this?

Answer 1

Many women with PCOS do not ovulate and clomiphene (or clomid) is used to induce ovulation. (copied from the website below) "Clomid fools the body into believing that the estrogen level is low. This altered feedback information causes the hypothalamus (an area of the brain) to make and release more gonadotropin releasing hormone (GnRH) which in turn causes the pituitary to make and release more FSH and LH. More follicle stimulating hormone and more luteinizing hormone should result in the release of one or more mature eggs - ovulation." I am not sure of the success rate, but I know of many women with PCOS who have gotten pregnant on their first or second round. There are several different dosages and I believe that most if not all women start out on 50 mg. and if that doesn't work after one or two rounds, the dosage is increased. I don't think it's suggested to do more than two rounds of Clomid a year as Clomid can make your body dependent on it and your chance of ovulating on your own is decreased. Many drs. won't allow women to take it for more than 6 cycles/months as taking it for longer is "not likely to improve the chances of success". And if it doesn't work at that point, women typically start with stronger forms of drugs like injectables. *Taking Clomid does increase the chance of having twins as more than one egg can be released at ovulation.*

Answer 2

"Clomiphene. This is the most common fertility drug, taken for five days at the beginning of each menstrual cycle. Clomiphene stimulates the release of follicle-stimulating hormone (FSH) by the pituitary gland. This acts on the ovaries and often triggers the ripening of a follicle and then ovulation, usually around five to 10 days after the last tablet is taken. Clomiphene's advantages is it's free from major side effects and has a low multiple pregnancy rate - only five to 10 percent. There's a possible link with ovarian cancer after 12 cycles so if conception isn't achieved after about six cycles, you may be advised to try ART instead. In the US, fertility drugs such as dexamethasone and metformin offer an alternative approach for some women"

"Polycystic ovary syndrome: Many women have benign ovarian cysts that don't affect fertility. But polycystic ovary syndrome (PCOS) interferes with ovulation and can cause fertility problems.

True PCOS is caused by too much male hormone being produced by the adrenal glands, leading to an abnormally high ratio of LH to FSH. The ovary becomes filled with 'cysts' - actually immature follicles which fail to generate eggs. Sufferers have infrequent periods, a tendency to obesity and excessive body hair"

I'm going to include the link to a trying to conceive forum that I think you might find useful. It's full of supportive women with boundless knowledge about these issues. There is also a special section of the forum for women who are using Clomiphene to talk about their experiences and to support one another. I learnt so much there that I doubt I would have learnt otherwise.

Answer 3

It can help women with PCOS get pregnant and it helps about 80% to ovulate and of them about 60% get pregnant.

Answer 4

That is something you want to talk to the MD about. Some people I believe get pregnant quickly.

Have you seen a reproductive endo? Many of them will try something not so harsh like Glucophage first to get women to ovulate on their own.