thuja oil (Cedar Leaf) safety and uses?

Answer 1

Thujone
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Thujone

Systematic name Thujone
Chemical formula C10H16O
Molecular mass 152.23 g/mol
Density 0.92 g/cm3
Solubility insoluble (water)
soluble (ethanol)
Melting point 201 °C
Boiling point xx.x °C
CAS number [76231-76-0]
SMILES xxxxx
Disclaimer and references
Thujone (C10H16O) is the chemical compound notable for its presence in the alcoholic beverage absinthe. It is a colourless liquid with a distinctive menthol odour. It is a ketone and a monoterpene, and is found in two stereoisomeric forms: (+)-3-thujone or α-thujone and (-)-3-thujone or β-thujone. Its formal name is sometimes given as bicyclo(3.1.0)hexan-3-one, 4-methyl-1-(1-methylethyl)-,(1S-(1-, 4-, 5-α))-(9CI); other names include isothujone and thujanone. It is used as a flavouring agent in certain foods and is a compound in a number of other food additives. It boils at 201°C and is insoluble in water although it is readily soluble in ethanol or diethyl ether.

Contents [hide]
1 Sources
2 Pharmacology
3 Regulations
3.1 European Union
3.2 United States
4 References



[edit]
Sources
Thujone is found in a number of plants, such as arborvitae (genus Thuja, hence the derivation of the name), Nootka Cypress, some junipers, mugwort, sage, tansy (25-77% in essential oil) and wormwood, most notably the Artemisia absinthium species, usually as a mix of isomers in a 1:2 ratio.

[edit]
Pharmacology
Although it was originally believed to be similar to tetrahydrocannabinol (THC), that has since been disproven. Most likely thujone antagonizes inhibition in the gamma-aminobutyric acid (GABA) receptor system.

In mice the median lethal dose, or LD50, is around 45 mg/kg, 0% mortality rate at 30 mg/kg and 100% at 60 mg/kg. Those exposed to the higher dose had convulsions that led to death in 1 minute. From 30 to 45 mg/kg the mice would experience muscle spasms in the legs which progressed to general convulsions until death or recovery. Pretreatment of diazepam, phenobarbital or 1 g/kg of ethanol protected against a lethal 100 mg/kg dose. [1]

There are few studies on humans and the LD50 isn't known. One study in the Journal of Studies of Alcohol administered 0.28 mg/kg thujone in alcohol, 0.028 mg/kg in alcohol and just alcohol to subjects. The high dose had a negative effect on attention performance. The lower dose showed no noticeable effect. [2] There is no evidence that any dose will cause hallucinations.

Thujone is best known as a component of the drink absinthe, as it is a component of natural oil of wormwood (Artemisia absinthium). Although it was believed to be the cause of absinthism, an alleged syndrome which caused epileptic fits and hallucinations in chronic absinthe drinkers, this has since been questioned. New studies of vintage absinthe, modern absinthe made with vintage recipes, and modern absinthe show very little thujone. Most absinthe studied, including the vintage, were below 10 mg/kg, and all were below EU regulations for bitters. [3] [4]

[edit]
Regulations
[edit]
European Union
Maximum thujone levels in the EU are: [5]

0.5 mg/kg in food not prepared with sage and non alcoholic beverages.
5 mg/kg in alcoholic beverages with 25% or less ABV.
10 mg/kg in alcoholic beverages with more than 25% ABV.
25 mg/kg in food prepared with sage.
35 mg/kg in alcohol labeled as bitters.
[edit]
United States
Foods or beverages that contain Artemisia species, White Cedar, oak moss, tansy or Yarrow must be thujone free.[6] Other herbs that contain thujone have no restrictions. For example, sage and sage oil (which can be 50%+ thujone) are on the Food and Drug Administration's list of Substances generally recognized as safe. [7]

Answer 2

Botanical Name: Thuja occidentalis

This oil is to be used only externally and with extreme caution. The ketone levels are high and can be neurotoxic if taken internally. Do not confuse with Cedar leaf or Cedarwood oil. This cedar tree is also called the arbor vitae tree. Historically used to remove growths and warts. This oil can be used in an infusion to clean the skin as an astringent to soothe poison oak, acne and cold sores. It strips oils from the skin. As an inhalant and in massage it treats neuralgia and sedates the nervous system. The scent of thuja is stimulating to the mind and sharpens thought.

Answer 3

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RE:
thuja oil (Cedar Leaf) safety and uses?

Answer 4

Thuja is excellent for getting rid of warts. Put thuja oil or cream directly on the wart, cover with a plaster, twice a day. Also you can use thuja tablets(homeopathic), then you are treating externally and internally.

Answer 5

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Answer 6

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