Which solvent is the best substitute in absence of 1chlorobutane?

Question

I'm doing my Ph. D. and I have a problem. i have a reaction mixture that needs separating within a week and in that time I can't have tthe solvent required ie 1chlorobutane. So can you suggest an alternative solvent.

Answer 1

So you need chlorobutane to run a column?

What about something similar, in terms of polarity, like chloropropane or chloropentane?

I was going to run a column once based on results from TLC using a pentane/acetone mixture. The lab ran out of pentane and the stock room was closed. My undergraduate research advisor suggested hexane instead. We tried it, it worked, and I was able to get the separation.