How to prepare 1 Molar Trifloruoacetic acid?

Answer 1

Dilute the stock solution.

Be careful, though. Trifluoroacetic is very noxious stuff. My undergrad organic teacher said that he handled inorganic acids for years, with no problem. First day he handled trifluoroacetic, he burned himself.

Answer 2

Ok to prepare a 1 Molar trifloruoacetic acid use this formula

Weight of acid needed = molar mass of acid x molarity x the number of mLs you need / 1000 mL

Once you worked out the weight you need place the acid in a
gradutated flask and fill with the solvent you wish to use to the mark you need to make.

Answer 3

The role of selenium as an antioxidant and anticancer agent is very well documented in the literature. Selenium compound showing the highest activity as a free radicals scavenger and as an anticancer agent should contain selenium at +4 oxidation level. The synthesis of selenitetriglycerides (named selol) was carried out in the Department of Drug Analysis at Warsaw Medical University (Polish Patent 1999). Selenitetriglycerides showed a dimeric structure. In a single dose toxicity studies performed in rats, LD50 was 100 mg Se kg(-1) after oral administration of selol. The subcutaneous and intraperitoneal administration of selol showed extremely low toxicity. The aim of this work was to develop a new specific method for the determination of Se(IV) in selol. We stated that selenitetriglycerides react quantitatively with trifluoroacetic acid (TFA) in dichloromethane giving a red-coloured conjugate. However, recorded spectrum showed the maximum absorption in the wavelength 380 nm. The optimal conditions of the reaction were established, namely temperature 35 degrees C and reaction time 35 min. The reaction was proved to be specific because neither selenites nor other selol constituents react with TFA. The constructed calibration curve obeyed the Lambert-Beer law in the range of 0.1-7.4 mg ml(-1). Molar absorption coefficient is epsilon =9.46 x 10(3) l mol(-1) cm(-1) and epsilon =2.36 x 10(5) l mol(-1) cm(-1) calculated for selenium and selenitetriglyceride dimer (m.w. 1972.72), respectively. Obtained results for selenium determination were confirmed by AAS method. The developed method showed specificity and high sensitivity.

Answer 4

Synthesis of Trifloruoacetic acid
Electrofluorination of acetic acid with the Simons method is the best way to obtain trifluoroacetic acid. The anodic reaction of the electrolysis of a mixture of hydrogen fluoride and acetic acid below the voltage at which elemental fluorine (F2) develops is a mild reaction which leaves the carboxylic group intact.

Trifluoroacetic acid (TFA) is a strong, hygroscopic, non-oxidizing, organic acid with a molecular formula C2HF3O2. The molecular structure is similar to acetic acid, with substitution of three fluorine atoms on the methyl group. The electronic-withdrawing nature of the fluorine atoms stabilizes the dissociated anion, leading to stronger acidity compared to acetic acid. TFA is a reagent used frequently in organic synthesis due to its nature as an organic-soluble strong acid. It is also frequently used as a buffer in liquid chromatography for separation of organic compounds, particularly peptides and small proteins.

Answer 5

Go to the chemical supply store and buy it. It's not something you'd do in your kitchen and certainly not without pretty extensive training in organic chemistry.

Be ready to show ID at the store and to answer lots of questions as to why you want it.

Answer 6

this is not a lab...it's ya