In vivo research is more suited to observe an overall effect than in vitro research, which is better suited to deduce mechanisms of action. In vitro research aims to describe and understand the effect of an experimental variable on a subset of an organism's components. In vitro research has the advantage over in vivo research that there are fewer variables which can confound an experiment, and that if an experimental effect is subtle the result will be more clearly visible.
In vivo research has the advantage, Whether the aim is to discover drugs or to gain knowledge of biological systems, the nature and properties of a chemical tool cannot be considered independently of the system it is to be tested in. Compounds that bind to isolated recombinant proteins are one thing; chemical tools that can perturb cell function another; and pharmacological agents that can be tolerated by a live organism and perturb its systems are yet another. If it were simple to ascertain the properties required to develop a lead discovered in vitro to one that is active in vivo, drug discovery would be as reliable as drug manufacturing.[1]
The massive adoption of low-cost, in vitro, molecular biology techniques has caused a move away from in vivo research, which is considered too idiosyncratic and, above all, expensive compared to its molecular counterpart. Currently, in vitro models and experiments are a vital and highly productive research tool.
The guinea pig was previously such a commonly used in vivo experimental model that they became part of idiomatic English: being a guinea pig for someone/something. Their use in research has been substantially replaced by the smaller, cheaper and faster breeding rats and mice.
As the term is in Latin, it is written in italics
http://en.wikipedia.org/wiki/In_vivo
2006-06-06 02:37:28
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answer #1
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answered by nyack 4
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The word vivo is associated with in vivo experiments or in vivo research. It means that research is being done on a living animal (animal that is alive) and not in a test tube.
2006-06-06 10:41:23
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answer #2
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answered by Munir B 3
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The word "vivo" is latin for "to live" or "to support life". "In vivo" is latin for "in the living", and describes experimentation performed on a whole animal. This differentiates biological experimentation on parts of an animal, such as cell culture or experiments on removed organs, which would not be considered in vivo, but rather in vitro.
"In vitro" is latin for "in glass", and it typically used as the opposite of in vivo, at least, as far as scientific experimentation is concerned..
2006-06-06 12:15:27
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answer #3
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answered by wcholberg 3
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Video In Video Out
2006-06-06 09:33:31
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answer #4
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answered by Smiddy 5
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viva is an interjection meaning long live
may b vivo has gotta do sumthng wid it
2006-06-06 09:34:21
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answer #5
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answered by mini 3
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