關於alzheimer的NICD與AICD

Question

可否請教一下各位高手 到底研究Alzheimer的path way裡
APP分別被gamma-secretase 與 beta-secretase分解後 所在membrane內產生之
NICD 與 AICD 是為何物?
謝謝大家的幫忙

Answer 1

do you mind an answer in english?

2006-07-12 06:52:40 補充：
I don't think NICD is the cleavage product of gamma-secretase acting on APP.

NICD is Notch intracellular domain, which is liberated when gamma-secretase cleaves Notch1. NICD is a key molecule in cellular differentiation that translocates to the nucleus where it acts as a transcriptional coactivator.

AICD is APP intracellular domain. AICD results from predominant cleavage after leucine 49 of the A-beta domain of APP, a position that is analogous to the cleavage of Notch that would generated NICD.

So.... NICD and AICD are cleavage products of two different substrate of gamma-secretase.

Hope this helps, more information can be found in the following citation:

Moehlmann T et al, Presenilin-1 mutations of leucine 166 equally affect the generation of the Notch and APP intracellular domains independent of their effect on Abeta 42 production., Proc Natl Acad Sci U S A. 2002 Jun 11;99(12):8025-30.

Answer 2

可以的 英文我能接受